HIV-1 (human immunodeficiency virus type-1) is the pathogenic retrovirus and causative agent of AIDS. The integrase enzyme offers an attractive target for anti-AIDS drug design because of its necessary for viral life cycle and lack of IN homologous enzymes in the human host. Structural features of L-chicoric acid are important for potency against HIV-1 integrase. So, in the present study, 2-D QSAR and interaction studies of some chicoric acid analogs was carried out by VLife MDS & Schrodinger molecular modeling interface. The developed QSAR models showed r2= 0.8503, pred_r2 = 0.8201 with MLR analysis. Docking study also revealed important interactions of these ligands with the active binding site of integrase enzyme. These studies are more significant guide to trace the features that really matter especially with respect to the design of novel compounds.
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